Worked in Ferrara. Was one of the leading artists of the school of Ferrara, together with Cosimo Tura and Ercole de Roberti.
In the early 1470-ies he moved to Bologna, where he painted the altar of the chapel Griffoni in the Church of San Petronio (1473). The Central panel of the altarpiece is in the National Gallery in London.
An outstanding artist of the school of Ferrara of the XV century, which was formed around the court of Borso d'este. Koss was born in Ferrara about 1436 he Studied at Tours Cosimo; influenced by Andrea Mantegna and Piero della Francesca.
Completed the painting of the Palazzo Schifanoia in Ferrara represent one of the most significant fresco cycles of secular content created in the Renaissance. The frescoes Hall of the months in the Palazzo Schifanoia on the 12 months of the year. They are divided into three tiers. In the upper case are placed a series of festive allegorical scenes, the bottom one is a few pictures from the life of the court of the Dukes d'este. Between them is a wide band with images of astrological symbols. After completion in 1470 work on the frescoes in the Palazzo Schifanoia that he was commissioned by the Duke Borso d'este, Francesco del Cossa moved from Ferrara to Bologna. The main work created by the artist in Bologna was the altarpiece for the chapel Griffoni in the Church of San Petronio (currently fragmented). Died Francesco del Cossa about 1478 in Bologna.
Francesco del Cossa Cossa was one of the greatest painters of Ferrara, which, according to General opinion, wrote so thin that his work had a strong energy and was unusually expressive.