Duveneck was born in a family of German immigrant Bernard Decker, and was the eldest son. Frank took the surname of his stepfather.
At the age of fifteen, Frank began to study painting under the guidance of local painters and decorators Benedictine churches – Johann Schmitt (1825-1898) and Wilhelm Lamprecht. He was later apprenticed in a craft company German Church decorators.Duveneck in 1869 went to Europe and entered the Royal Academy of painting in Munich.
At the Academy he learns from Wilhelm von Diez (1839-1907) and Wilhelm Leibl, studying realistic painting style.
Born into a family of German immigrants. After the death of his father, Bernhard Dekker, Frank's mother marries again, and the boy takes the surname of his stepfather. F. Duveneck begins to study art in Cincinnati. In 1869 he went to Germany and entered the Royal Academy of arts in Munich in the class of William chase. Upon graduation, opens in Munich its own artistic workshop. In 1873 F. Duveneck returned to America and 2 years teaching at the mechanics Institute Ohio. In 1875 he was again in Munich, in 1876, the artist went to Paris, and the next year — 9 months in Venice. In 1879 he commits a new voyage to Italy. In 1886 Duveneck married his pupil, 20-year-old native of Boston, the artist Elizabeth Booth (who lived at that time in Florence and studied painting at F. Duveneck). After 2 years Elizabeth dies in Paris of pneumonia. Having survived this tragedy, Frank is on time, leaves the painting and turns to sculpture.
Back in the US, the artist settles in Cincinnati, where it remains until the end of his days as a teacher at the local Academy of arts. Among his students of note John. W. Alexander, Joseph Rodefer de Kamp, Kenyon Cox, John Henry Twachtman.
In the beginning of his career, F. Duveneck she paints mainly portraits in a realistic manner. After a stay in France and Italy, he also creates landscapes and domestic scenes, gradually evolving in the direction of impressionism. Wrote as oil painting and etchings.
Since 1905 — member of the National Academy of design. In 1915 F. Duveneck was exhibited at the world exhibition in San Francisco.