Francesco Granacci studied in the workshop of Domenico Ghirlandaio, and assisted him in writing of his paintings using tempera instead of oil paints. By order of Lorenzo de ' Medici Granacci participated in the painting of the Florence San Marco. Later he worked with Leonardo da Vinci, Michelangelo and Raphael.In 1508, Granacci moved to Rome, where together with other artists helped Michelangelo in painting the Sistine chapel.
The style Granacci was influenced by Filippino Lippi and fra Bartolomeo.
Granacci mentioned in the "Lives of the artists" by Giorgio Vasari.