Among the museum's exhibits, visitors can see the Predella degli Uffizi, a unique work by Florentine masters of the 15th century.
The Museum of Sacred Art was founded in the 1990s to house works of art from churches that were no longer considered safe from theft and damage to masterpieces. The protection of works of art is the link between Montespertoli and the Galleria degli Uffizi panel depicting Christ of Sorrows and Stories from the Life of St. Peter the Martyr. During World War II, from 1942 to 1945, most of the art collections from Florence's museums were kept safe in the Castel Montegufoni in Montespertoli. Notable "guests" included such masterpieces as two versions of Cimabue and Giotto's Maesta, Paolo Uccello's The Battle of San Romano, and Botticelli's The Spring.