Studied painting from B. Campi and B. Gati. The scenic heritage of Sofonisba is fairly large: it includes about fifty works, most of which relates to the years of stay in Cremona.
In 1560 Anguissola (Anguissola) got the position of artist at the court of the Spanish king Philip II.
Fleeing from Spain, Anguissola (Anguissola) settled in Genoa, where he opened his own school of painting.
Italian painter, master of portrait genre. Sofonisba born in Cremona (Lombardy). She was the oldest of seven children, six of whom were girls. Her father Amilcar Angiola belonged to the elite aristocratic circle of Genoa. The mother of Sophonisba Bianca Ponzone also came from a famous aristocratic family. She died early, when Sofonisba was only five years old.
Being already well known, Anguissola visited in 1558 in Milan, where he painted the portrait of the Duke of Alba, who recommended her to the Spanish king Philip II. Next year Anguissola was invited to the Spanish court, which was the recognition of her talent.
Sofonisba Anisole was 27 years old when she left her family and came to Spain to the court of the king. In the winter of 1559−1560 she arrived at Madrid to serve as court artist and the court lady of Queen Elizabeth of Valois, third wife of king Philip II, whom he just married. She soon won the respect and confidence of the young Queen.
Anguissola spent the following years mainly by creating the official court portraits, including the Queen and other members of the Royal family, sister of Philip II, Juan, and son, don Carlos. Her portraits of Elizabeth of Valois and Anna of Austria (fourth wife of Philip II) dynamic and full of life.
On the way home in Cremona, Sofonisba became acquainted with Orazio Lomellino, a former captain of the ship on which she sailed. They loved each other at first sight and soon were married in January of 1580, in Pisa. Sofonisba was at that time 47 years old, and her husband was considerably younger than her. Husband strongly supported Sofonisba Anguissola in her work, which was the basis for their long and happy marriage. They settled in Genoa, where in a big house lived the family of her husband. Sofonisba was created the perfect conditions for creativity, private apartments and private Studio.
Many artists came to her to visit to learn and share opinions on the directions in the development of art. She has created her own style, which many artists sought to emulate. Its success opened the way to other women artists of the Renaissance such as Lavinia Fontana, Barbara Longhi, Fede Galicia and Artemesia Gentileschi.
In the last years of his life Angiola wrote not only portraits but also paintings on religious themes, as in the days of his youth. However, many of her paintings were subsequently lost.
A good trade of her husband and a generous pension from Philip II allowed her to paint freely and live comfortably. She was a leading portrait painter in Genoa until he moved to Palermo in the last years of his life. In 1620 she created his last self-portrait.